A common compound: 18013-97-3, name is Diethyl 2,5-dibromoterephthalate, belongs to esters-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 18013-97-3
Under nitrogen protection,Diethyl 2,5-dibromoterephthalate (2g, 5.26mmol), compound 1 (7.03, 13.68mmol), and dry toluene (40mL) were added to a 100mL two-necked flask, and nitrogen was bubbled through to remove it. After half an hour of oxygen, Pd (PPh3) 4 (116 mg, 0.1 mmol) was quickly added, and the reaction solution was heated to 110 C and refluxed for 24 hours. After the reaction was stopped, the reaction solution was cooled to room temperature, and the toluene solvent was distilled off with a rotary evaporator. It was then separated and purified with a chromatography column using petroleum ether / dichloromethane as the eluent (volume ratio of 3: 2) to obtain Compound 2 (2.85 g, 81.2%) as a brown solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 18013-97-3, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Nanjing University of Science and Technology; Yu Jiangsheng; Tang Weihua; Zhang Zhuohan; Liu Xin; Zhou Jie; Geng Renyong; Yang Linqiang; (25 pag.)CN110606856; (2019); A;,
Ester – Wikipedia,
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