Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Quality Control of cis-3-Hexenyl acetate, 3681-71-8, Name is cis-3-Hexenyl acetate, molecular formula is C8H14O2, belongs to esters-buliding-blocks compound. In a document, author is Yamanashi, Takehiko, introduce the new discover.
Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model
Accumulating evidence suggests that elevated inflammation contributes to the pathophysiology of post-traumatic stress disorder (PTSD) and that anti-inflammatory drugs might be a new treatment strategy for PTSD. It has been reported that beta-hydroxybutyrate (BHB), one of the main ketone bodies produced, can have an anti-inflammatory and antidepressant effect. Here, we investigated the potential anti-anxiety and anti-inflammatory effects of BHB using a rodent PTSD model, induced by single prolonged stress (SPS). Male, Sprague-Dawley rats were employed in this study. Repeated administration of BHB attenuated SPS-induced anxiety-related behaviors evaluated by the elevated plus maze test. SPS increased the serum levels of TNF-alpha and IL-1 beta. In contrast, BHB administration partially attenuated the increase of serum TNF-alpha. These findings demonstrate that BHB exerts its anxiolytic effects, possibly by inhibiting systemic TNF-alpha. Hence, BHB may be a novel therapeutic candidate for the treatment of PTSD.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 3681-71-8. Quality Control of cis-3-Hexenyl acetate.