Zimmermann, Lisa published the artcileBenchmarking the in Vitro Toxicity and Chemical Composition of Plastic Consumer Products, SDS of cas: 111-11-5, the main research area is toxicity chem composition plastic consumer product.
Plastics are known sources of chem. exposure and few, prominent plastic-associated chems., such as bisphenol A and phthalates, have been thoroughly studied. However, a comprehensive characterization of the complex chem. mixtures present in plastics is missing. In this study, we benchmark plastic consumer products, covering eight major polymer types, according to their toxicol. and chem. signatures using in vitro bioassays and non-target high resolution mass spectrometry. Most (74 %) of the 34 plastic extracts contained chems. triggering at least one endpoint, including baseline toxicity (62 %), oxidative stress (41 %), cytotoxicity (32 %), estrogenicity (12 %) and antiandrogenicity (27 %). In total, we detected 1411 features, tentatively identified 213, including monomers, additives and non-intentionally added substances, and prioritized 25 chems. Extracts of polyvinyl chloride (PVC) and polyurethane (PUR) induced the highest toxicity whereas polyethylene terephthalate (PET) and high-d. polyethylene (HDPE) caused no or low toxicity. High baseline toxicity was detected in all “”bioplastics”” made of polylactic acid (PLA). The toxicities of low-d. polyethylene (LDPE), polystyrene (PS) and polypropylene (PP) varied. Our study demonstrates that consumer plastics contain compounds that are toxic in vitro but remain largely unidentified. Since the risk of unknown compounds cannot be assessed, this poses a challenge to manufacturers, public health authorities and researchers alike. However, we also demonstrate that products not inducing toxicity are already on the market.
Environmental Science & Technology published new progress about Antiandrogens. 111-11-5 belongs to class esters-buliding-blocks, name is Methyl octanoate, and the molecular formula is C9H18O2, SDS of cas: 111-11-5.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics