Hashan, Mohammad Rashidul published the artcileEffect of nitazoxanide on diarrhea: A systematic review and network meta-analysis of randomized controlled trials, SDS of cas: 55981-09-4, the main research area is review nitazoxanide antidiarrheals diarrhea; Antibiotic; Diarrhea; Meta-analysis; Nitazoxanide; Systematic review.
We aimed to systematically review evidence pertaining to the safety and efficacy of nitazoxanide in treating infectious diarrhea. On Sept. 21, 2017, we identified relevant studies using 12 databases. The estimates of the included studies were pooled as a risk ratio (RR). We conducted a network and pairwise random-effects meta-anal. for both direct and indirect comparisons of different organisms that are known to cause diarrhea. The primary and secondary anal. outcomes were clin. response until cessation of illness, parasitol. response and adverse events. We included 18 studies in our anal. In cryptosporidiosis, the overall estimate favored nitazoxanide in its clin. response in comparison with placebo RR 1.46 [95% CI 1.22-1.74; P-value <0.0001]. Network meta-anal. among patients with Giardia intestinalis showed an increase in the probability of diarrheal cessation and parasitol. responses in comparison with placebo, RR 1.69 [95% CI 1.08-2.64, P-score 0.27] and RR 2.91 [95% CI 1.72-4.91, P-score 0.55] resp. In Clostridium difficile infection, the network meta-anal. revealed a non-significantly superior clin. response effect of nitazoxanide to metronidazole 31 days after treatment RR 1.21 [95% CI 0.87-1.69, P-score 0.26]. In Entamoeba histolytica, the overall estimate significantly favored nitazoxanide in parasitol. response with placebo RR 1.80 [95% CI 1.35-2.40, P-value < 0.001]. We highlighted the effectiveness of nitazoxanide in the cessation of diarrhea caused by Cryptosporidium, Giardia intestinalis and Entamoeba histolytica infection. We also found significant superiority of NTZ to metronidazole in improving the clin. response to G. intestinalis, thus it may be a suitable candidate for treating infection-induced diarrhea. To prove the superiority of NTZ during a C. difficile infection may warrant a larger-scale clin. trial since its superiority was deemed insignificant. We recommend nitazoxanide as an appropriate option for treating infectious diarrhea. Acta Tropica published new progress about Antidiarrheals. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, SDS of cas: 55981-09-4.
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