Al-Rajhi, Aisha M. H. published the artcileMolecular Interaction Studies and Phytochemical Characterization of Mentha pulegium L. Constituents with Multiple Biological Utilities as Antioxidant, Antimicrobial, Anticancer and Anti-Hemolytic Agents, Name: Methyl docosanoate, the main research area is Mentha Bacillus luteolin chrysoeriol antioxidant antimicrobial anticancer mol interaction; Mentha pulegium; anticancer; anticoagulant; antimicrobial; antioxidant.
Multiple biol. functions of Mentha pulegium extract were evaluated in the current work. Phytochem. components of the M. pulegium extract were detected by Gas Chromatog.-Mass Spectrometry (GC-MS) and High-performance liquid chromatog. (HPLC). Moreover, M. pulegium extract was estimated for antioxidant potential by 2,2-Diphenyl-1-picryl-hydrazyl-hydrate (DPPH) free radical scavenging, antimicrobial activity by well diffusion, and anticoagulant activity via prothrombin time (PT) and activated partial thromboplastin time (APTT). GC-MS anal. detected compounds including cholesterol margarate, stigmast-5-en-3-ol, 19-nor-4-androstenediol, androstan-17-one, pulegone-1,2-epoxide, isochiapin B, dotriacontane, hexadecanoic acid and neophytadiene. Chrysoeriol (15.36 μg/mL) was followed by kaempferol (11.14 μg/mL) and 7-OH flavone (10.14 μg/mL), catechin (4.11 μg/mL), hisperdin (3.05 μg/mL), and luteolin (2.36 μg/mL) were detected by HPLC as flavonoids, in addition to ferulic (13.19 μg/mL), cinnamic (12.69 μg/mL), caffeic (11.45 μg/mL), pyrogallol (9.36 μg/mL), p-coumaric (5.06 μg/mL) and salicylic (4.17 μg/mL) as phenolics. Antioxidant activity was detected with IC50 18 μg/mL, hemolysis inhibition was recorded as 79.8% at 1000 μg/mL, and PT and APTT were at 21.5 s and 49.5 s, resp., at 50 μg/mL of M. pulegium extract The acute toxicity of M. pulegium extract was recorded against PC3 (IC50 97.99 μg/mL) and MCF7 (IC50 80.21 μg/mL). Antimicrobial activity of M. pulegium extract was documented against Bacillus subtilis, Escherichia coli, Pseudomonasaureus, Candida albicans, Pseudomonas aeruginosa, but not against black fungus Mucor circinelloides. Mol. docking was applied using MOE (Mol. Operating Environment) to explain the biol. activity of neophytadiene, luteolin, chrysoeriol and kaempferol. These compounds could be suitable for the development of novel pharmacol. agents for treatment of cancer and bacterial infections.
Molecules published new progress about Anticoagulants. 929-77-1 belongs to class esters-buliding-blocks, name is Methyl docosanoate, and the molecular formula is C23H46O2, Name: Methyl docosanoate.
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