Mowery, Patricia published the artcileDiscovery of an indole-substituted furanone with tubulin polymerization inhibition activity, Application of Ethyl 2-hydroxyacetate, the main research area is indole furanone drug discovery synthesis anticancer tubulin polymerization inhibition; Anticancer; Furanone; Indole; Tubulin.
Analogs of diarylpyrrolinone lead compound I were prepared and tested for anti-proliferative activity in U-937 cancer cells. Alterations of I focused on modifying the two nitrogen atoms: the pyrrolinone nitrogen atom was substituted with a Pr group or replaced with an oxygen atom (furanone); and the substituents on the indole nitrogen were varied. These changes led to the discovery of a furanone analog II with sub-micromolar anti-cancer potency and tubulin polymerization inhibition activity.
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, Application of Ethyl 2-hydroxyacetate.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics