Pang, Wenwen published the artcileAnticancer activities of Zanthoxylum bungeanum seed oil on malignant melanoma, COA of Formula: C13H18O3, the main research area is Zanthoxylum malignant melanoma seed oil anticancer; Cell cycle arrest; Invasion; Malignant melanoma; Seed oil Apoptosis; Zanthoxylum bungeanum.
Zanthoxylum bungeanum Maxim. (ZBM), a Chinese herb medicine and food additive, has been shown to have broad-spectrum beneficial effects. However, the anticancer activities of its seed have not been reported.for the first time investigated the anti-proliferation activity of seed oil of ZBM (ZBSO) on melanoma A375 cells as well as the underlying mechanisms. The chem. composition of ZBSO was analyzed by Ultra Performance Liquid Chromatog. A375 cells exposure at different concentrations of ZBSO to examine the selectivity vs. normal skin cells, invasion, apoptosis and cell cycle arrest. Furthermore, transcriptome anal. was employed to investigate potential anticancer mechanisms of ZBSO. Major compounds of ZBSO were identified and unsaturated fatty acid made up the major compound ZBSO-treated A375 cells showed more typical apoptotic morphol. features than normal cells. ZBSO can significantly inhibit invasion and proliferation of A375 cells by G1 phase arrest and induction of apoptosis. Transcriptome anal. showed that ZBSO may affect cell cycle and MAPK signaling pathway of A375 cells. ZBSO possessed anticancer activities that were selectively effective to A375 cells. This study support the hypothesis that ZBSO is a capable candidate for anti-melanoma agent, and provide new insights for future work on investigating the utilization of ZBSO in malignant melanoma treatment.
Journal of Ethnopharmacology published new progress about Antitumor agents. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, COA of Formula: C13H18O3.
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