Application of 207346-42-7

The synthetic route of 207346-42-7 has been constantly updated, and we look forward to future research findings.

207346-42-7, A common heterocyclic compound, 207346-42-7, name is Methyl 2-amino-4,5-difluorobenzoate, molecular formula is C8H7F2NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 30; 2-(5-chlorothiophen-2-yl)-2-(‘4-(6-fluoro-7-(methylaminoV2,4-dioxo-l,2-dihvdroquinazolin- 3(4H)-ylN)-3-methoxybenzamido)acetic acid (51); Scheme 7; [0151] To difluoroanthranalide Ic (5.69 g, 30 mmol), was added phosgene in toluene ((1.9 M, 160 mL, 300 mmol). The reaction mixture was stirred at rt overnight, concentrated in vacuo, evaporated from toluene (20 mL), and dried under vacuum to afford a light beige solid 8a. The material was found to give the desired urea when treated with ammonia but was not otherwise characterized.

The synthetic route of 207346-42-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PORTOLA PHARMACEUTICALS, INC.; WO2008/36843; (2008); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics