Eronen, Aleksi E. K. published the artcileSynthesis of Diaryl Hydroxyl Dicarboxylic Acids from Amino Acids, Synthetic Route of 140-11-4, the main research area is aryl hydroxyl dicarboxylic acid synthesis amino acid; safety glass failure microwave.
Herein we report a unique method for preparing diaryl hydroxyl dicarboxylic acids in a diastereospecific manner. The three-component reaction occurs between amino acid, aromatic aldehyde, and primary alc. in alk. solutions under microwave-assisted conditions. The dicarboxylic acids are isolated as sodium salts in high yields (up to 77%) by direct precipitation from the reaction solution The exptl. results suggest that the diastereospecificity originates from a [3,3]-sigmatropic rearrangement followed by a sodium-assisted hydride transfer. As further shown, the previously unreported dicarboxylic acids are easily turned into corresponding δ-lactones. Safety: possible glass failure on account of pressure buildup in microwave.
Journal of Organic Chemistry published new progress about Aldol condensation (MPV/aldol condensation sequence for cinnamaldehyde synthesis). 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Synthetic Route of 140-11-4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics