A common heterocyclic compound, 33993-24-7, name is Cyclopropanecarboxylic anhydride, molecular formula is C8H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 33993-24-7.
General procedure: To a stirred solution of 7 (107 mg, 0.20 mmol), TEA (82 muL,0.60 mmol) and DMAP (10 mg, 0.08 mmol) in dry DCM (10mL) acetic anhydride (57 muL, 0.60 mmol) was added dropwiseat 0 C. Then, the reaction mixture was allowed to stir at roomtemperature overnight. The mixture was concentrated anddiluted with H2O (20 mL) and extracted with EtOAc (2¡Á10mL). The combined organic layers were washed with H2O(2¡Á20 mL), brine (20 mL), and dried over Na2SO4. The mixturewas cooled to room temperature, slowly diluted with H2O(100 mL) and extracted with EtOAc (2¡Á100 mL). The combinedorganic layers were washed with H2O (2¡Á150 mL), brine(150 mL), dried over Na2SO4 and concentrated. The residuewas purified by flash chromatography using 5% EtOAc inpetroleum ether to yield 77 mg (0.13 mmol, 65%) of product asa white pure solid.
The synthetic route of Cyclopropanecarboxylic anhydride has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Xiao-Yin; Zhang, Shu-Yong; Li, Jing; Liu, Hua-Nan; Xie, Xin; Nan, Fa-Jun; Acta Pharmacologica Sinica; vol. 35; 11; (2014); p. 1463 – 1472;,
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