4606-07-9, A common compound: 4606-07-9, name is Ethyl cyclopropanecarboxylate, belongs to esters-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
Example 126a 3-Cyclopropyl-3-oxopropanenitrile 126a To a solution of acetonitrile (0.34 mL, 6.58 mmol) in THF (3 mL) at -78 C. under N2 protection was added lithium di-i-propylamide (3.3 mL, 2M in THF, 6.58 mmol) drop-wise. The reaction mixture was stirred at -78 C. for 3 h. Then ethyl cyclopropanecarboxylate (0.50 g, 4.38 mmol) in THF (2 mL) was added and the mixture was allowed to warm to room temperature for a period of 1 h. Water (2 mL) was added and the solvent was removed under reduced pressure. Dichloromethane (2 mL) was added and the pH of the mixture was adjusted to 5 with 2N HCl. It was then extracted with dichloromethane (5 mL*2). The combined organic layer was dried over Na2SO4 and concentrated to afford 126a as a yellow oil, which was used in the next step without further purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl cyclopropanecarboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GENENTECH, INC.; Crawford, James John; Ortwine, Daniel Fred; Wei, BinQing; Young, Wendy B.; US2013/116246; (2013); A1;,
Ester – Wikipedia,
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