Nykaza, Trevor V. published the artcilePIII/PV=O Catalyzed Cascade Synthesis of N-Functionalized Azaheterocycles, Application of Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate, the main research area is azaheterocycle preparation organophosphorus catalyst cascade; cross-coupling; cyclization; nitrogen heterocycles; organocatalysis; phosphorus.
An organocatalytic method for the modular synthesis of diverse N-aryl and N-alkyl azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) and a hydrosilane reductant to drive the conversion of ortho-functionalized nitroarenes into azaheterocycles through sequential intermol. reductive C-N cross coupling with boronic acids, followed by intramol. cyclization. This method enables the rapid construction of azaheterocycles from readily available building blocks, including a regiospecific approach to N-substituted benzimidazoles and quinoxalinediones.
Angewandte Chemie, International Edition published new progress about Benzimidazoles Role: SPN (Synthetic Preparation), PREP (Preparation). 2982-53-8 belongs to class esters-buliding-blocks, name is Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate, and the molecular formula is C11H13NO6, Application of Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics