Preparation and in-vitro evaluation of 0.05% 5-fluorouracil solid lipid nanoparticle gel in the treatment of actinic keratosis was written by Aswathy, B.;Ravindran, Remya;Ramkumar, R. P.;Apaduvanpadavath, Labeeb. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2022.Synthetic Route of C21H44O5 The following contents are mentioned in the article:
The present study focused on the formulation and in-vitro evaluation of 0.05% 5-fluorouracil solid lipid nanoparticle gel in treating actinic keratosis. The in-vitro release profile of solid lipid nanoparticle gel is higher than the marketed cream formulation; thus, we can reduce the dose of formulation by this method. This is prepared using tween 80, tween 20, glycerol monostearate, glycerol, and lecithin. Pre-formulation studies for the pure drug were conducted, and formulations were evaluated based on viscosity, encapsulation efficiency and in-vitro drug release study using franz diffusion cell. FTIR study of pure drug-polymer and formulation proves there is no chem. interaction between them. Formulation SLN2 had appropriate viscosity of 1738.34, the highest encapsulation efficiency of 94.45%, drug loading 31.97%. SLN2 shows 95% cell viability. The in-vitro release study was found to have a zero-order release profile. Compared to all other formulations, this indicates the predominant mechanism of drug release is diffusion. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Synthetic Route of C21H44O5).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Synthetic Route of C21H44O5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics