Novel N-thioamide analogues of pyrazolylpyrimidine based piperazine: Design, synthesis, characterization, in-silico molecular docking study and biological evaluation was written by Vekariya, Mayur K.;Patel, Dhaval B.;Pandya, Pranav A.;Vekariya, Rajesh H.;Shah, Prapti U.;Rajani, Dhanji P.;Shah, Nisha K.. And the article was included in Journal of Molecular Structure in 2019.Category: esters-buliding-blocks The following contents are mentioned in the article:
(Thioureidopiperazinyl)pyrimidinyl pyrazolecarboxylates I (R = Ph, Me, Et, n-Pr, Bu, i-Pr, t-Bu, H2C:CHCH2, cyclohexyl, PhCH2, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 3-ClC6H4, 4-ClC6H4, 4-FC6H4, 2,4-Cl2C6H3, 3-IC6H4, 4-MeC6H4, PhCO, 4-O2NC6H4, 2,3-Cl2C6H3, 2,6-Cl2C6H3, 2-ClC6H4) were prepared and tested as potential antituberculosis, antimalarial, antibacterial, and antifungal agents. Their physicochem., biol. permeabilities into cells and through the blood-brain barrier, and hERG inhibition were calculated and the binding to Plasmodium falciparum dihydrofolate reductase, Escherichia coli FabH, and Staphylococcus aureus hydrolase were calculated for selected compounds This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Category: esters-buliding-blocks).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics