CuII and AuIII complexes with glycoconjugated dithiocarbamato ligands for potential applications in targeted chemotherapy was written by Pettenuzzo, Nicolo;Brustolin, Leonardo;Coltri, Elisa;Gambalunga, Alberto;Chiara, Federica;Trevisan, Andrea;Biondi, Barbara;Nardon, Chiara;Fregona, Dolores. And the article was included in ChemMedChem in 2019.COA of Formula: C16H22O11 The following contents are mentioned in the article:
This work is focused on the synthesis, characterization, and preliminary biol. evaluation of bio-conjugated AuIII and CuII complexes with the aim of overcoming the well-known side effects of chemotherapy by improving the selective accumulation of an anticancer metal payload in malignant cells. For this purpose, carbohydrates were chosen as targeting agents, exploiting the Warburg effect that accounts for the over expression of glucose-transporter proteins (in particular GLUTs) in the phospholipid bilayer of most neoplastic cells. We linked the dithiocarbamato moiety to the C1 position of three different monosaccharides:
(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.COA of Formula: C16H22O11
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics