Guo, Yongbiao published the artcileChiral Spirocyclic Phosphoric Acid-Catalyzed Synthesis of 4-Alkyl-3,4-dihydropyrimidin-2(1H)-one Derivatives by Asymmetric Biginelli Reactions, Recommanded Product: Methyl 3-oxovalerate, the publication is Asian Journal of Organic Chemistry (2020), 9(4), 626-630, database is CAplus.
A chiral spirocyclic phosphoric acid-catalyzed asym. Biginelli reaction based on aliphatic aldehydes was realized for the synthesis of biol. important and synthetically useful 4-alkyl-3,4-dihydropyrimidin-2-(1H)-one (4-alkyl-DHPM) skeletons I [R = Et, n-Bu, n-heptyl, etc.; R1 = Me, Et, t-Bu, etc.; R2 = Me, Et] in good yield and with high levels of enantioinduction. The utility of this transformation was further demonstrated by direct thionation and C-C/C-N bond construction to provide a series of 4-alkyl-DHPMs derivatives I without any loss of optical activity, providing streamlined access to the formal synthesis of Batzelladine A.
Asian Journal of Organic Chemistry published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Recommanded Product: Methyl 3-oxovalerate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics