Diebold, Martin published the artcileImmunological Predictors of Dimethyl Fumarate-Induced Lymphopenia, Product Details of C6H8O4, the publication is Annals of Neurology (2022), 91(5), 676-681, database is CAplus and MEDLINE.
Treatment with di-Me fumarate (DMF) leads to lymphopenia and infectious complications in a subset of patients with multiple sclerosis (MS). Here, we aimed to reveal immune markers of DMF-associated lymphopenia. This prospective observational study longitudinally assessed 31 individuals with MS by single-cell mass cytometry before and after 12 and 48 wk of DMF therapy. Employing a neural network-based representation learning approach, we identified a CCR4-expressing T helper cell population neg. associated with relevant lymphopenia. CCR4-expressing T helper cells represent a candidate prognostic biomarker for the development of relevant lymphopenia in patients undergoing DMF treatment.
Annals of Neurology published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Product Details of C6H8O4.
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