Wang, Yun-Peng published the artcileAn efficient approach to angular tricyclic molecular architecture via Nazarov-like cyclization and double ring-expansion cascade, HPLC of Formula: 30414-53-0, the publication is Nature Communications (2022), 13(1), 2335, database is CAplus and MEDLINE.
A modular and efficient method for constructing angular tri-carbocyclic architectures containing quaternary carbon center(s), e.g., I (R = Me) from 1,3-dicycloalkylidenyl ketones, e.g., II is established, which involves an unconventional synergistic cascade of a Nazarov cyclization and two ring expansions. It features high selectivity, mild conditions and convenient operation, wide scope and easy availability of substrate. Substitution at the 4πe-system with electron-donating group favors this reaction, while that with electron-withdrawing group or proton disfavors. The electron-donating group directs the initial ring expansion at its own site, while the p-π- or n-π- associated substituent favors selectively the later ring expansion near its location because of the beneficial maintenance of an original conjugated system. The stereoselectivity has proved to be governed by either the steric effect at the expanded rings, or the migration ability of the migrating atom. D. Functional Theory calculation suggests that the initial Nazarov cyclization would be the rate-determining step. A racemic total synthesis of the natural (±)-waihoensene is realized in 18 steps by use of this methodol.
Nature Communications published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C15H14O, HPLC of Formula: 30414-53-0.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics