Baker, Jennifer R. published the artcileAmino Alcohols as Potential Antibiotic and Antifungal Leads, Application of (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, the publication is Molecules (2022), 27(7), 2050, database is CAplus and MEDLINE.
Five focused compound libraries based on prior studies of the author. were synthesized and screened for antibiotic and anti-fungal activity against S. aureus, E. coli, K. pneumoniae, P. aeruginosa, A. baumannii, C. albicans and C. neoformans. Low levels of activity, at the initial screening concentration of 32μg/mL, were noted with analogs of (Z)-2-(3,4-dichlorophenyl)-3-phenylacrylonitriles which made up the first two focused libraries produced. Modifications of the terminal aromatic moiety were explored through epoxide installation by flow chem. mediated ring opening aminolysis with discreet sets of amines to the three new focused libraries of afforded amino alcs. Three new focused libraries were developed from substituted anilines, cyclic amines, and Ph linked heterocyclic amines. The aniline-based compounds were inactive against the bacterial and fungal lines screened but the introduction of piperidine, piperazine, or morpholine, showed >50% inhibition when evaluated at 32μg/mL compound concentration against methicillin-resistant Staphylococcus aureus. Aromatic substituted piperidine or piperazine switched library activity from antibacterial to anti-fungal activity with compounds containing (4-methylpiperazin-1-yl),(4-hydroxyphenylpiperazin-1-yl) and (4-cyclohexylpiperazin-1-yl) showing >95% inhibition of Cryptococcus neoformans var. grubii H99 growth at 32μg/mL, while few acrylonitriles showed 32μg/mL against Staphylococcus aureus.
Molecules published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Application of (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate.
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