Chiral Phosphoric-Acid-Catalyzed Regioselective and Enantioselective C7-Friedel-Crafts Alkylation of 4-Aminoindoles with Trifluoromethyl Ketones was written by Cai, Lu;Zhao, Yunlong;Huang, Tongkun;Meng, Shanshui;Jia, Xian;Chan, Albert S. C.;Zhao, Junling. And the article was included in Organic Letters in 2019.Name: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate The following contents are mentioned in the article:
A highly regioselective and enantioselective C7-Friedel-Crafts alkylation of 4-aminoindoles with trifluoromethyl ketones promoted by a spirocyclic phosphoric acid was developed. This strategy was applicable to various substituted trifluoromethyl ketones and 4-aminoindole derivatives, affording the corresponding C7-functionalized indole derivatives, bearing a pharmaceutically interesting trifluoromethylated tertiary alc. scaffold, in 21%-98% yields with up to >99% enantiomeric excess (ee). This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Name: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate).
Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Name: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate
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