Selective Acylation of Aryl- and Heteroarylmagnesium Reagents with Esters in Continuous Flow was written by Heinz, Benjamin;Djukanovic, Dimitrije;Ganiek, Maximilian A.;Martin, Benjamin;Schenkel, Berthold;Knochel, Paul. And the article was included in Organic Letters in 2020.Formula: C11H9F3O3 The following contents are mentioned in the article:
A selective acylation of readily accessible organomagnesium reagents with com. available esters proceeds at convenient temperatures and short residence times in continuous flow. Flow conditions allow us to prevent premature collapse of the hemiacetal intermediates despite noncryogenic conditions, thus furnishing ketones in good yields. Throughout, the coordinating ability of the ester and/or Grignard was crucial for the reaction outcome. This was leveraged by the obtention of several bisaryl ketones using 2-hydroxy ester derivatives as substrates. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Formula: C11H9F3O3).
Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Formula: C11H9F3O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics