Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities was written by Medellin, Derek C.;Zhou, Qiong;Scott, Robert;Hill, R. Matthew;Frail, Sarah K.;Dasari, Ramesh;Ontiveros, Steven J.;Pelly, Stephen C.;van Otterlo, Willem A. L.;Betancourt, Tania;Shuster, Charles B.;Hamel, Ernest;Bai, Ruoli;LaBarbera, Daniel V.;Rogelj, Snezna;Frolova, Liliya V.;Kornienko, Alexander. And the article was included in Journal of Medicinal Chemistry in 2016.Product Details of 763-69-9 The following contents are mentioned in the article:
Docking studies of tubulin-targeting C2-substituted 7-deazahypoxanthine analogs of marine alkaloid rigidins led to the design and synthesis of compounds containing linear C2-substituents. The C2-alkynyl analog I was found to have double- to single-digit nanomolar antiproliferative IC50 values and showed statistically significant tumor size reduction in a colon cancer mouse model at nontoxic concentrations These results provide impetus and further guidance for the development of these rigidin analogs as anticancer agents. This study involved multiple reactions and reactants, such as Ethyl 3-ethoxypropanoate (cas: 763-69-9Product Details of 763-69-9).
Ethyl 3-ethoxypropanoate (cas: 763-69-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 763-69-9
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Ester – an overview | ScienceDirect Topics