Stereocontrolled synthesis of vitamin A through a double elimination reaction. A novel convergent C10 + C10 route was written by Otera, Junzo;Misawa, Hiromitsu;Onishi, Takashi;Suzuki, Shigeaki;Fujita, Yoshiji. And the article was included in Journal of Organic Chemistry in 1986.Safety of (2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate The following contents are mentioned in the article:
The first convergent C10 + C10 route for vitamin A has been developed. The double elimination reaction of β-alkoxy I (R = tetrahydropyranyl, 4-methyltetrahydropyranyl, MeCHOEt, CH2OMe) or δ-halo sulfones II (R1 = Cl, Br) proceeds with excellent stereocontrol to afford the all-trans or 13-cis isomers of 90-95% purity. The double elimination reaction of I is initiated by deprotonation of an allylic hydrogen whereas the reaction II proceeds through the Michael addition of KOMe. Nevertheless, formation of the reactive intermediate III under mild conditions is crucial to achieving a smooth double elimination reaction in both cases. This study involved multiple reactions and reactants, such as (2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate (cas: 37905-02-5Safety of (2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate).
(2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate (cas: 37905-02-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of (2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics