Use of inhibitors of prostaglandin synthesis in patients with breast cancer was written by Powles, T. J.;Dady, P. J.;Williams, Judith;Easty, G. C.;Coombes, R. C.. And the article was included in Advances in Prostaglandin and Thromboxane Research in 1980.Product Details of 5003-48-5 The following contents are mentioned in the article:
Effects of antiinflammatory and antiosteolytic agents were studied in patients with breast cancer, since it is known that some human breast tumors release osteolytic substances which cause breakdown of bone. Benoral (I) [5003-48-5], an aspirin-paracetamol conjugate, prevented bone metastasis in rats, but I (4 g twice a day for 18 mo) given to patients with breast cancer did not affect overall development of bone metastasis. In breast cancer patients with osteolytic bone metastasis, aspirin [50-78-2] and indomethacin [53-86-1] had no antiosteolytic activity; flurbiprofen [5104-49-4], calcitonin [9007-12-9], and mithramycin [18378-89-7] had some antiosteolytic activity but in terms of cancer therapy this was trivial. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Product Details of 5003-48-5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 5003-48-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics