Synthesis and Activity of Fluorescent Isoprenoid Pyrophosphate Analogues was written by Kim, MeeKyoung;Kleckley, Troy S.;Wiemer, Andrew J.;Holstein, Sarah A.;Hohl, Raymond J.;Wiemer, David F.. And the article was included in Journal of Organic Chemistry in 2004.Application In Synthesis of (2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate The following contents are mentioned in the article:
New fluorescent analogs of farnesol and geranylgeraniol were prepared and then converted to the corresponding pyrophosphates. These analogs incorporate anthranylate or dansyl-like groups anchored to the terpenoid skeleton through amine bonds that would be expected to be relatively stable to metabolism After addition of the alcs. or the pyrophosphates to the culture medium, their fluorescence is readily observed inside a human-derived leukemia cell line. Enzyme assays have revealed that the farnesyl pyrophosphate analog is an inhibitor of FTase, while the corresponding alc. is not. These results, together with Western blot analyses of cell lysates, indicate that the farnesyl pyrophosphate analog penetrates the cells as an intact pyrophosphate and that it does so at a biol. relevant concentration This study involved multiple reactions and reactants, such as (2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate (cas: 37905-02-5Application In Synthesis of (2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate).
(2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate (cas: 37905-02-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application In Synthesis of (2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics