Gao, Min published the artcilePhase-Transfer-Catalyzed Asymmetric Annulations of Alkyl Dihalides with Oxindoles: Unified Access to Chiral Spirocarbocyclic Oxindoles, Category: esters-buliding-blocks, the publication is Organic Letters (2022), 24(3), 875-880, database is CAplus and MEDLINE.
A general phase-transfer-catalyzed asym. (n+1) (n = 4 or 5) annulation reaction, featuring the direct coupling of simple oxindoles I (R1 = H, 5-Me, 6-OMe, 6-Cl, etc.) with alkyl dihalides R2(R3)C=C(CH2I)(CH2)2I (R2 = R3 = H, Me, Et, Ph n-pentyl; R2R3 = -(CH2)5) and e.g., 1-(2-iodoethyl)-2-(iodomethyl)benzene that are allylic/benzylic and non-allylic/benzylic, has been developed to provide previously inaccessible cyclopentane- II and III and cyclohexane-fused spirooxindole IV (R4 = H, 6,7-(OMe)2, 6-Cl) scaffolds with high yields and enantioselectivities (88-95% ee). Along with a broad scope and mild conditions, the new protocol also enables a two-step and gram-scale synthesis of the core of the drug ubrogepant.
Organic Letters published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Category: esters-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics