Zhou, Changqian published the artcileChemical composition, antibacterial activity and study of the interaction mechanisms of the main compounds present in the Alpinia galanga rhizomes essential oil, Application of Methyl 3-phenyl-2-propenoate, the publication is Industrial Crops and Products (2021), 113441, database is CAplus.
In this research, the antibacterial activity and the interaction mechanisms of the major chem. constituent present in the Alpinia galanga rhizomes essential oil (AGREO) were investigated. Et cinnamate, Me cinnamate and n-pentadecane were the major components of AGREO. The antibacterial mechanism of AGREO on Enterohemorrhagic Escherichia coli O157:H7 (EHEC O157) was evaluated and the results proved that the potent antibacterial activity of AGREO was due to higher passive permeability of bacterial cell membrane, followed by crucial intracellular components efflux. Addnl., AGREO disrupted the intracellular physiol. metabolism of EHEC O157, including inhibition of P-type ATPases activity and down-regulation expression of four virulence genes associated with EHEC infections. Notably, mol. docking studies suggested that Et cinnamate probably competed with the structural NAD(P)+ for the binding sites of glucose-6-phosphate dehydrogenase (G6PD), resulting in a decrease in G6PD activity with subsequent suppression of respiratory metabolism The spectroscopic techniques and mol. docking studies proved that the AGREO major components were prone to bind to the minor groove of DNA.
Industrial Crops and Products published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is 0, Application of Methyl 3-phenyl-2-propenoate.
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