Levoin, Nicolas published the artcileNovel and highly potent histamine H3 receptor ligands. Part 1: withdrawing of hERG activity, Quality Control of 50670-76-3, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(18), 5378-5383, database is CAplus and MEDLINE.
Pre-clin. investigation of some aryl-piperidinyl ether histamine H3 receptor antagonists revealed a strong hERG binding. To overcome this issue, we have developed a QSAR model specially dedicated to H3 receptor ligands. This model was designed to be directly applicable in medicinal chem. with no need of mol. modeling. The resulting recursive partitioning trees are robust (80-85% accuracy), but also simple and comprehensible. A novel promising lead I emerged from our work and the structure-activity relationships are presented.
Bioorganic & Medicinal Chemistry Letters published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Quality Control of 50670-76-3.
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https://en.wikipedia.org/wiki/Ester,
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