Shengule, Sudhir R. published the artcileDiastereoselective Pictet-Spengler reactions of a tethered 2-aminoimidazole, Formula: C10H19NO3, the publication is Australian Journal of Chemistry (2014), 67(2), 184-191, database is CAplus.
The diastereoselective Pictet-Spengler reaction of aminopropyl-2-aminoimidazole with enantiopure aldehydes was investigated. With amino acid-derived aldehydes, anti-stereochem. was favored, with a diastereoselectivity up to 92% achievable. The absolute stereochem. of the products was determined through synthesis of a rigid derivative and from NMR data in combination with mol. modeling. The diastereoselectivity dependent on the steric bulk of the amino acid side chain and independent of the nitrogen protecting group. Lewis acids catalyzed the reaction but did not affect the diastereoselectivity.
Australian Journal of Chemistry published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C9H9NO, Formula: C10H19NO3.
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