Wu, Ying-Ta's team published research in Current Drug Delivery in 1

Wu, Ying-Ta published the artcileA new N-acetylgalactosamine containing peptide as a targeting vehicle for mammalian hepatocytes via asialoglycoprotein receptor endocytosis, Formula: C14H19NO8, the publication is Current Drug Delivery (2004), 1(2), 119-127, database is CAplus and MEDLINE.

Galactoside-containing cluster ligands have high affinity for asialoglycoprotein receptors (ASGP-r), which are found in abundance in mammalian parenchymal liver cells. These ligands may be conjugated with a therapeutic drug to improve the efficiency of delivery to diseased liver cells. This report describes a new synthetic route towards clustering glycopeptides containing N-acetyl-D-galactosamine (GalNAc). The building block Fmoc-α-(ah-Ac₃GalNAc)-L-glutamate allowed access to the target compound YEEE(α-ah-GalNAc)₃, a structural mimic of YEE(ah-GalNAc)₃, via solid phase peptide synthesis (SPPS). Fatty acid, polylysine, fluorescein and biotin conjugates further demonstrate the facility of the described method. Using fluorescein labeling and ¹³¹I labeling, in vitro and in vivo assays confirmed that YEEE(α-ah-GalNAc)₃ possesses both specificity and affinity to the liver, similar to the agent YEE(ah-GalNAc)₃, which targets liver lesions. The synthesis described in this report represents a considerable improvement in synthesizing a ligand for ASGP-r by simplifying both the preparation of the starting material and the procedure for conjugating the galactosidase cluster to drugs.

Current Drug Delivery published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C6H9BN2O2, Formula: C14H19NO8.

Referemce:
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