As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37466-90-3 name is Ethyl 3,4-diaminobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 37466-90-3
General procedure: Compound 3 (10 mmol) was dissolved in ethylene glycol (50 mL) andthen compound 2 (10 mmol) and a small amount of polyphosphoricacid were added to the stirred solution which was then refluxed forseveral hours (the reaction was monitored by TLC). On completion ofthe reaction, the mixture was poured into ice water. The solution wastreated with 30% sodium hydroxide to slight alkalinity (pH = 9). Theprecipitated solid was filtered off, recrystallised from ethanol anddried in vacuo to give compound 4.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 3,4-diaminobenzoate, and friends who are interested can also refer to it.
Reference:
Article; Wang, Xinying; Liu, Yizhou; Xu, Juan; Jiang, Fanwei; Kang, Congmin; Journal of Chemical Research; vol. 40; 10; (2016); p. 588 – 590;,
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