Lee, Alice published the artcileGeneral Solid-Phase Method for the Preparation of Mechanism-Based Cysteine Protease Inhibitors, Recommanded Product: Ethyl 2-mercaptopropanoate, the publication is Journal of the American Chemical Society (1999), 121(43), 9907-9914, database is CAplus.
A general method has been developed for the expedient solid-phase synthesis of ketone-based cysteine protease inhibitors. The synthesis approach was designed to allow the introduction of diverse functionality at all variable sites about the ketone carbonyl using readily available precursors. The chloromethyl ketone scaffold is attached to the solid support through the newly developed hydrazine linker. Successful nucleophilic displacement of the support-bound α-chloro hydrazones with carboxylates, thiolates, and amines provides entry to the acyloxymethyl, mercaptomethyl, and amidomethyl ketone classes of cysteine protease inhibitors. Further transformations followed by cleavage from support provides the fully substituted ketone products in 40-100% overall yields after release from support. Significantly, racemization of the α-stereocenter does not occur during loading onto support, nucleophilic displacement, or cleavage from support.
Journal of the American Chemical Society published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Recommanded Product: Ethyl 2-mercaptopropanoate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics