Wuest, Frank R.’s team published research in Journal of Labelled Compounds and Radiopharmaceuticals in 49 | CAS: 5205-11-8

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C9H5ClO2, Application of 3-Methylbut-2-en-1-yl benzoate.

Wuest, Frank R. published the artcile11C-C bond formation by palladium-mediated cross-coupling of alkenylzirconocenes with [11C]methyl iodide, Application of 3-Methylbut-2-en-1-yl benzoate, the publication is Journal of Labelled Compounds and Radiopharmaceuticals (2006), 49(2), 91-100, database is CAplus.

Hydrozirconation of substituted propynes followed by coupling with [11C]methyl iodide was applied for preparation of methyl-group labeled alkenes. Reaction fo RCCMe with Cp2ZrHCl with subsequent treatment with 11C-Me iodide in the presence of Pd(PPh3)4 yielded the corresponding RCH:CMe(11CH3) (R = Ph, PhOCH2, tBu, n-Pr, tBuMe2SiOCH2, HOCH2, 4-NO2C6H4OCH2). The palladium complex Pd(PPh3)4 proved to be superior to Pt(PPh3)4 or Ni(PPh3)4 as transition metal complex. The scope and limitations of the novel palladium-mediated cross-coupling reaction of alkenylzirconocenes with [11C]methyl iodide were tested with various internal alkynes. After heating at 60° for 6 min radiochem. yields of up to 75% (based upon [11C]methyl iodide) could be achieved.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C9H5ClO2, Application of 3-Methylbut-2-en-1-yl benzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics