Antitumor mechanism of the essential oils from two succulent plants in multidrug resistance leukemia cell was written by Poma, Paola;Labbozzetta, Manuela;Mccubrey, James A.;Ramarosandratana, Aro Vonjy;Sajeva, Maurizio;Zito, Pietro;Notarbartolo, Monica. And the article was included in Pharmaceuticals in 2019.Synthetic Route of C15H22O2 The following contents are mentioned in the article:
Drug resistance remains a major challenge in the treatment of cancer. The multiplicity of the drug resistance determinants raises the question about the optimal strategies to deal with them. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain several chem. classes of compounds whose heterogeneity of active moieties can help prevent the development of drug resistance. In the present paper, we analyzed, by gas chromatog.-mass spectrometry the chem. composition of the essential oil of the leaves of Kalanchoe beharensis obtained by hydrodistillation and compared the chem. composition of its essential oil with that of Cyphostemma juttae. Our results demonstrated the anticancer and proapoptotic activities of both species against acute myeloid leukemia on an in vitro model and its multidrug resistant variant involving NF-κB pathway. The essential oils of both species produced a significant decrease in many targets of NF-κB both at mRNA and protein levels. The results corroborate the idea that essential oils may be a good alternative to traditional drugs in the treatment of cancer, especially in drug resistant cancer. This study involved multiple reactions and reactants, such as 2-Ethylhexyl benzoate (cas: 5444-75-7Synthetic Route of C15H22O2).
2-Ethylhexyl benzoate (cas: 5444-75-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C15H22O2
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