Formulation and evaluation of ezetimibe loaded solid lipid nanoparticles was written by Chilukuri, Chandraprakash;Haq, S. Muhammad Fazal Ul. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2022.SDS of cas: 31566-31-1 The following contents are mentioned in the article:
Ezetimibe is an anti Hyperlipidemic drug with low bioavailability (35%) and poor aqueous solubility (0-00846 mg/L.) The present study was focused to enhance the bioavailability of ezetimibe. Drug loaded solid lipid nanoparticles were prepared by using high shear homogenization and ultrasonication method using glycerol mono sterate as lipid and tween 80, poloxamer 188 as surfactants. Prepared solid lipid nanoparticles were characterized for particle size, surface morphol. and thermal properties. Evaluation studies like entrapment efficiency, Invitro drug release studies, and stability studies. The optimized formulation of ezetimbe loaded solid lipid nanoparticles exhibited particle size (432 nm), zeta potential (-13.8mV) and poly dispersity index (0.168). Thermal property studies performed by using differential scanning calorimetry showed no chem. interaction between drug and lipid. Entrapment efficiency of optimized formulation was found to be 88.72 ± 0.21%. scanning electron microscope study revealed solid lipid nanoparticles were spherical in shape with smooth surface. invitro drug release studies showed a drug release of 89.2 ± 0.2% for optimized formulation. Stability studies performed on the optimized formulation at different temperatures for 2 mo revealed there is slight decrease in the stability of drug loaded solid lipid nanoparticles. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1SDS of cas: 31566-31-1).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 31566-31-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics