Formulation and Evaluation of Topical Biodegradable Films Loaded with Levofloxacin Lipid Nanocarriers was written by Abdel-Rashid, Rania S.;El-leithy, Eman S.;Abdel-monem, Raghda. And the article was included in AAPS PharmSciTech in 2022.Electric Literature of C21H44O5 The following contents are mentioned in the article:
Skin ulcers have increased sharply due to rise in the incidence of obesity and diabetes. This study investigated lipid nanocarriers as a strategy to improve the efficacy of levofloxacin (LV) in penetrating skin. Two surfactant types and different lipid mixtures were used in preparation of lipid nanocarriers. Mean particle size, percentage entrapment efficiency (%EE), in vitro release, and antimicrobial activity were examined The selected formula was incorporated into a chitosan (CS) film that was subjected to physic-chem. characterization and ex vivo permeation study. The selected formula showed particle size, PDI, and ZP: 80.3 nm, -0.21, and -26 mV, resp., synchronized with 82.12%EE. In vitro release study showed slow biphasic release of LV from lipid nanocarriers. The antimicrobial effect illustrated statistically significant effect of lipid nanocarriers on decreasing the min. effective concentration (MIC) of LV, particularly against E. coli. The optimized nanocarriers鈥?formula loaded into CS film was clear, colorless, translucent, and smooth in texture. Based on the release profiles, it could be speculated that the CS film loaded with LV nanocarriers can maintain the antibacterial activity for 4 consecutive days. Thus, the local delivery of the drug in a sustained release manner could be predicted to enhance the therapeutic effect. Further clin. studies are strongly recommended. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Electric Literature of C21H44O5).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C21H44O5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics