Yang, Dan; Wu, Xiong; Zheng, Xiao-Jie; Xie, Jian-Hua; Zhou, Qi-Lin published their research in Organic Letters in 2021. The article was titled 《Dynamic Kinetic Resolution of γ-Substituted Cyclic β-Ketoesters via Asymmetric Hydrogenation: Constructing Chiral Cyclic β-Hydroxyesters with Three Contiguous Stereocenters》.Product Details of 609-08-5 The article contains the following contents:
An efficient asym. hydrogenation of racemic γ-substituted cyclic β-ketoesters I (R = Ph, 2-naphthyl, 2-furyl, etc.; n = 1, 2) via dynamic kinetic resolution to provide chiral cyclic β-hydroxy esters II with three contiguous stereocenters is reported. Using a chiral spiro iridium catalyst (R)-5 (Ir-SpiroSAP), a series of racemic γ-aryl/alkyl substituted cyclic β-ketoesters I was hydrogenated to the corresponding chiral cyclic β-hydroxy esters II in high yields (84-97%) with good to excellent enantioselectivities (69->99% ee) and cis,cis-selectivities (up to >99:1). In the experiment, the researchers used many compounds, for example, Diethyl 2-methylmalonate(cas: 609-08-5Product Details of 609-08-5)
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Product Details of 609-08-5
Referemce:
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Ester – an overview | ScienceDirect Topics