Gao, Qian; Lu, Jia-Ming; Yao, Lingyun; Wang, Siqi; Ying, Jun; Wu, Xiao-Feng published an article in 2021. The article was titled 《Cobalt-catalyzed direct C-H carbonylative synthesis of free (NH)-indolo[1,2-a]quinoxalin-6(5H)-ones》, and you may find the article in Organic Letters.Application of 329-59-9 The information in the text is summarized as follows:
A cobalt-catalyzed direct C-H carbonylative reaction of N-(2-(1H-indol-1-yl)phenyl)picolinamides for the synthesis of (NH)-indolo[1,2-a]quinoxalin-6(5H)-one skeletons has been developed. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source and picolinamide as the traceless directing group, various free (NH)-indolo[1,2-a]quinoxalin-6(5H)-ones were obtained in good yields (up to 88%). Addnl., a series of product derivatizations were demonstrated, and the core fragment of PARP-1 inhibitor C can be readily constructed by this protocol. The results came from multiple reactions, including the reaction of Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Application of 329-59-9)
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Application of 329-59-9
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