Synthetic Route of C4H7NO2SIn 2013 ,《Stereoselective or exclusive synthesis of ethyl (Z)-2-(2-substituted-thiazol-4-yl)pent-2-enoates from ethyl (E/Z)-2-(2-bromoacetyl)pent-2-enoate》 was published in Synlett. The article was written by Zhai, Jiao-Jiao; Jiang, Jian-An; Zhang, Shun-Li; Chen, Cheng; Liu, Hong-Wei; Liao, Dao-Hua; Ji, Ya-Fei. The article contains the following contents:
A stereoselective or exclusive approach to a series of Et (Z)-2-(2-substituted-thiazol-4-yl)pent-2-enoates e. g., I from Et (E/Z)-2-(2-bromoacetyl)pent-2-enoate and thioureas or thioamides was reported in good yields. This approach involves a quaternary carbon stereocontrolled cis-configuration formation, and opportunely blocking a potential E/Z isomerization. The practical applicability was highlighted by the synthesis of (Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)pent-2-enoic acid, a com. important side-chain material of cefcapene pivoxil, in a two-step procedure. In the part of experimental materials, we found many familiar compounds, such as Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Synthetic Route of C4H7NO2S)
Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Synthetic Route of C4H7NO2S
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