Yang, Shuo; An, Xiao-De; Qiu, Bin; Liu, Rui-Bin; Xiao, Jian published an article in 2021. The article was titled 《Access to Polycyclic Indole-3,4-fused Nine-membered Ring via Cascade 1,6-Hydride Transfer/Cyclizations》, and you may find the article in Organic Letters.Recommanded Product: 329-59-9 The information in the text is summarized as follows:
A cascade aldimine condensation/1,6-hydride transfer/Mannich-type cyclization of indole-derived phenylenediamine with aldehydes was developed for one-step construction of polycyclic indole 3,4-fused skeleton I [R = Ph, 3-MeC6H4, 4-MeOC6H4, etc.; R1 = H, 9-Cl, 10-Me, etc.; R2 = H, 4-Ph]. Aldehyde served as a key to start the whole process, including 1,6-hydride transfer enabled β-C(sp3)-H activation of the secondary amine. The challenges of construction of medium-sized rings were addressed via hydride transfer chem. After reading the article, we found that the author used Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: 329-59-9)
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: 329-59-9Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics