Safety of Diethyl 2-methylmalonateIn 2020 ,《Site-Selective and Chemoselective C-H Functionalization for the Synthesis of Spiroaminals via a Silver-Catalyzed Nitrene Transfer Reaction》 was published in ACS Catalysis. The article was written by Harada, Shingo; Kobayashi, Mayu; Kono, Masato; Nemoto, Tetsuhiro. The article contains the following contents:
Although intense research over the last 2 decades revealed a diverse proficiency of nitrene species in chem. disciplines, control of the selectivity in the reaction manifold has remained a challenge. Authors report herein the development of site-selective and chemoselective C-H functionalization involving nitrene species to synthesize densely functionalized spiroaminals. A rhodium catalyst generally used in nitrene chem. gave amide C-N insertion products and/or the corresponding ketones, whereas a silver catalyst with an achiral bisoxazoline (BOX) ligand provided C-H insertion products. Mechanistic anal. based on integrated exptl. and computational studies indicated that the nitrene transfer occurred through an asynchronous concerted process involving triplet spin-correlated radical pairs, affording the corresponding stereodefined spiromols. The experimental process involved the reaction of Diethyl 2-methylmalonate(cas: 609-08-5Safety of Diethyl 2-methylmalonate)
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Safety of Diethyl 2-methylmalonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics