Fantinel, Mariane; Valiati, Nayara; Moro, Pedro A. M.; Sa, Marcus M. published their research in Tetrahedron in 2021. The article was titled 《Amino-modified Merrifield resins as recyclable catalysts for the safe and sustainable preparation of functionalized α-diazo carbonyl compounds》.Quality Control of Ethyl 3-oxopentanoate The article contains the following contents:
Amino-functionalized polystyrene polymers derived from Merrifield resins were prepared and characterized. These basic materials were successfully employed as heterogeneous catalysts in the diazo transfer reaction to 1,3-dicarbonyl compounds R1C(O)CH2C(O)R2 [R1 = R2 = Me, Ph, MeO; R1 = Me, R2 = Ph; R1 = Me, Et, ClCH2, Ph, etc., R2 = EtO; R1R2 = (CH2)3, OCMe2O, etc.] furnishing the corresponding diazo compounds R1C(O)C(:N2)C(O)R2 in good to excellent yields and in relatively short reaction times. In addition, the work-up and purification protocols are simple and do not generate large amounts of waste, which are important features in sustainable catalysis and environmentally benign processes. The feasibility of the recovery and reuse of the amino-modified catalysts were also verified, since they can be employed up to five times without appreciable loss of catalytic activity. This straightforward procedure can be readily scaled up to gram scale, enabling the wide application of this method. The synthetic potential was demonstrated through the two-step preparation of 2-amino-N-dodecylacetamide (ANDA), a small mol. of com. relevance. After reading the article, we found that the author used Ethyl 3-oxopentanoate(cas: 4949-44-4Quality Control of Ethyl 3-oxopentanoate)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Quality Control of Ethyl 3-oxopentanoate
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Ester – an overview | ScienceDirect Topics