Quality Control of Ethyl 3-oxopentanoateIn 2020 ,《Semi-Industrial Fluorination of β-Keto Esters with SF4 : Safety vs Efficacy》 was published in Synlett. The article was written by Trofymchuk, Serhii A.; Kliukovskyi, Denys V.; Semenov, Sergey V.; Khairulin, Andrii R.; Shevchenko, Valerii O.; Bugera, Maksym Y.; Tarasenko, Karen V.; Volochnyuk, Dmitriy M.; Ryabukhin, Sergey V.. The article contains the following contents:
The possibility of deoxofluorination of β-keto esters using SF4 was investigated. The scope and limitation of the reaction were determined The efficient method for the synthesis of β,β-difluorocarboxylic acids was elaborated based on the reaction. The set of mentioned acids, being the perspective building blocks for medicinal chem., were synthesized on multigram scale. The safety of SF4 use was discussed. The described method does not improve upon the safety of using SF4, but practical recommendations for working with the reagent were proposed. Despite the hazards of using toxic SF4, a significant increase of efficacy in the synthesis of medicinal-chem.-relevant building blocks, based on the reaction, in comparison with earlier described approaches was shown. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxopentanoate(cas: 4949-44-4Quality Control of Ethyl 3-oxopentanoate)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Quality Control of Ethyl 3-oxopentanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics