《Design, Synthesis, and Pharmacological Evaluation of First-in-Class Multitarget N-Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors》 was published in ChemMedChem in 2020. These research results belong to Rodrigues, Daniel A.; Guerra, Fabiana S.; Sagrillo, Fernanda S.; Pinheiro, Pedro de Sena M.; Alves, Marina A.; Thota, Sreekanth; Chaves, Lorrane S.; Sant’Anna, Carlos M. R.; Fernandes, Patricia D.; Fraga, Carlos A. M.. HPLC of Formula: 403-33-8 The article mentions the following:
Targeting histone deacetylases (HDACs) and phosphatidylinositol 3-kinases (PI3Ks) is a very promising approach for cancer treatment. This manuscript describes the design, synthesis, in vitro pharmacol. profile, and mol. modeling of a novel class of N-acylhydrazone (NAH) derivatives that act as HDAC6/8 and PI3Kα dual inhibitors. The surprising selectivity for PI3Kα may be related to differences in the conformation in the active site. Cellular studies showed that these compounds act in HDAC6 inhibition and the PI3/K/AKT/mTOR pathway. The compounds that are selective for inhibition of HDAC6/8 and inhibit PI3Kα show potential for the treatment of cancer. The experimental part of the paper was very detailed, including the reaction process of Methyl 4-fluorobenzoate(cas: 403-33-8HPLC of Formula: 403-33-8)
Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.HPLC of Formula: 403-33-8
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