《One-pot, multi-component synthesis of ethyl (E)-1-(3-ethoxy-3-oxoprop-1-en-1-yl)-2-aryl-2,5-dihydro-1H-benzo[b][1,4]diazepine-3-carboxylate derivatives》 was published in Tetrahedron Letters in 2020. These research results belong to Tan, Hong-bo; Wang, Yin-feng; Xu, Jia; Hu, Chun-sheng. Reference of Ethyl propiolate The article mentions the following:
A new methodol. for the synthesis of novel benzo[b][1,4]diazepine derivatives via a one-pot, multi-component reaction of benzaldehyde, o-phenylenediamine, and Et propiolate has been developed. Readily available starting materials, operationally simple, metal-free reaction conditions, simplicity of product isolation and good yields are key advantages of this methodol. The structure of the benzo[b][1,4]diazepines were confirmed by NMR, HRMS and XRD. In addition to this study using Ethyl propiolate, there are many other studies that have used Ethyl propiolate(cas: 623-47-2Reference of Ethyl propiolate) was used in this study.
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Reference of Ethyl propiolate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics