In 2022,Delamare, Aline; Naulet, Guillaume; Kauffmann, Brice; Guichard, Gilles; Compain, Guillaume published an article in Chemical Science. The title of the article was 《Hexafluoroisobutylation of enolates through a tandem elimination/allylic shift/hydrofluorination reaction》.Product Details of 609-14-3 The author mentioned the following in the article:
The first general method to introduce the hexafluoroisobutyl group into ketoesters, malonates, 1,3-diketones, Schiff base esters and malononitrile C(R)(R1)(R2)CH2CH(CF3)2 [R = C(O)Me, C(O)OEt, C(O)C6H5, etc.; R1 = C(O)OEt, C(O)Me, CN, etc.; R2 = Me, i-Pr, Bn, etc.] was reported. The reaction occurs through an elimination/allylic shift/hydrofluorination cascade process which efficiently overcomes the usual fluoride β-elimination observed with α-CF3-vinyl groups. The alkali metal bases, a pentafluorinated alkene is obtained predominantly, whereas the use of tetrabutylammonium fluoride (TBAF) allows hydrofluorination to occur. This tandem process represents a conceptually new pathway to synthesize bis-trifluoromethylated compounds This methodol. was applied to the multigram-scale synthesis of enantiopure (S)-5,5,5,5′,5′,5′-hexafluoroleucine. In the part of experimental materials, we found many familiar compounds, such as Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Product Details of 609-14-3)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Product Details of 609-14-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics