Tkachuk, Volodymyr V.; Shishkanu, Vyacheslav O.; Tkachuk, Tetiana M.; Shishkina, Svitlana V.; Hordiyenko, Olga V. published an article on January 31 ,2021. The article was titled 《2-Carbamimidoylbenzoic Acid as a New Effective and Available Precursor for the Synthesis of Substituted 2-(Pyrimidin-2-yl)-benzoic Acids》, and you may find the article in Synthesis.COA of Formula: C6H10O3 The information in the text is summarized as follows:
A new approach to the synthesis of 2-(pyrimidin-2-yl)benzoic acids I (R = Me, Et, Ph, OH, NH2) based on the ring contraction of the 2-carbamimidoylbenzoic acid with 1,3-dicarbonyl compounds R1CH2C(O)OR2 (R1 = C(O)Me, C(O)Et, C(O)Ph, C(O)OEt, CN; R2 = Me, Et), and their synthetic equivalent has been developed. The intramol. condensation of the obtained acids with 1,3-dielectrophiles proceeds with the formation of the 4,6-dihydropyrimido[2,1-a]isoindole-4,6-diones II (R = Me, Et, Ph, NH2), the pyrrolidone ring of which is easily opened under the action of weak nucleophiles. The reaction of 2-carbamimidoylbenzoic acid with chromones III (R3 = H, CF3; R4 = 4-chlorophenyl, 2-nitrophenyl), which have an aryloxy group at 3-position does not stop at the step of pyrimidine ring formation and undergoes further spontaneous cyclization into 2-(benzo[4,5]furo[3,2-d]pyrimidin-2-yl)benzoic acids IV. The results came from multiple reactions, including the reaction of Methyl 3-oxovalerate(cas: 30414-53-0COA of Formula: C6H10O3)
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.COA of Formula: C6H10O3
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