An, Yi; Zhang, Fang; Du, Guangfen; Cai, Zhihua; He, Lin published their research in Organic Chemistry Frontiers in 2021. The article was titled ãConstruction of 6H-benzo[c]thiochromenes via a tandem reaction of arynes with thionoestersã?Product Details of 403-33-8 The article contains the following contents:
A mild and transition-metal free tandem reaction for the construction of 6H-benzo[c]thiochromenes was developed. Thionoesters reacted with two mols. of arynes through a Diels-Alder cycloaddition/nucleophilic arylation process to afford 6-alkoxy-6-aryl-6H-benzo[c]thiochromenes I [R = Me, n-Bu, Bn, etc.; R1 = H, Me; R2 = H, Me, F, Cl, Br; R3 = H; R4 = H, Me, MeO; R5 = H, F; R6 = H, F; R7 = H, Me; R2R3 = CH=CH-CH=CH; Ar = Ph, 3-MeOC6H4, 2,5-di-MeC6H3, 3,4-di-FC6H3] in 37-80% yields. In addition, the Diels-Alder cycloaddition/aromatization tandem reaction of thionoesters with one mol. of aryne provided the construction of 6-alkoxyl-6H-benzo[c]thiochromenes II [R8 = Me, Et, n-Pr; R9 = H, F, Br; R10 = H, Me, Br, CH=CH2; R11 = H; R12 = H, F; R13 = H, F; R10R11 = CH=CH-CH=CH; R12R13 = CH=CH-CH=CH] in 51-75% yields. In the part of experimental materials, we found many familiar compounds, such as Methyl 4-fluorobenzoate(cas: 403-33-8Product Details of 403-33-8)
Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Product Details of 403-33-8
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics