ãPhotochemical chemoselective alkylation of tryptophan-containing peptidesã?was written by Laroche, Benjamin; Tang, Xinjun; Archer, Gaetan; Di Sanza, Riccardo; Melchiorre, Paolo. HPLC of Formula: 7524-52-9This research focused ontryptophan peptide photochem chemoselective alkylation light radical precursor; peptide coupling alkylation mechanism enantioselective diastereoselective synthesis. The article conveys some information:
We report a photochem. method for the chemoselective radical functionalization of tryptophan (Trp)-containing peptides. The method exploits the photoactivity of an electron donor-acceptor complex generated between the tryptophan unit and pyridinium salts. Irradiation with weak light (390 nm) generates radical intermediates right next to the targeted Trp amino acid, facilitating a proximity-driven radical functionalization. This protocol exhibits high chemoselectivity for Trp residues over other amino acids and tolerates biocompatible conditions. In addition to this study using H-Trp-OMe.HCl, there are many other studies that have used H-Trp-OMe.HCl(cas: 7524-52-9HPLC of Formula: 7524-52-9) was used in this study.
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.HPLC of Formula: 7524-52-9
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