Vu, Cuong M.; Le, Khoa B.; Vo, Uyen N.; Van, Vy D. T.; Nguyen, Anh T.; Phan, Nam T. S.; Le, Nhan T. H.; Nguyen, Tung T. published their research in Tetrahedron Letters on December 10 ,2020. The article was titled ãRecyclable CuFe2O4 for the synthesis of 2,3-disubstituted indolesã?Application In Synthesis of Methyl 3-oxovalerate The article contains the following contents:
A method for the CuFe2O4-catalyzed coupling of 2-iodo- or 2-bromoanilines 2-X-RC6H3NH2 (R = H, 4-trifluoromethoxy, 5-trifluoromethyl, etc.; X = I or Br) and acetylacetone or isosteric 1,3-diketones R1C(O)CH2C(O)R2 (R1 = Me, ethyl; R2 = ethoxy, methoxy) to afford 2,3-disubstituted indoles I (R3 = H, 5-bromo, 6-Me, etc.) has been developed. The superparamagnetic material showed superior activity in comparison to other ferrites or copper-based metal-organic frameworks. Functionalities including ester, cyano, and halogen groups were compatible with the reaction conditions. The CuFe2O4 catalyst was easily recoverable and reusable and offers a convenient pathway to afford synthetically useful heterocycles. In addition to this study using Methyl 3-oxovalerate, there are many other studies that have used Methyl 3-oxovalerate(cas: 30414-53-0Application In Synthesis of Methyl 3-oxovalerate) was used in this study.
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Application In Synthesis of Methyl 3-oxovalerate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics